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KMID : 0903520080510030219
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2008 Volume.51 No. 3 p.219 ~ p.222
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Herbicidal Activity and Molecular Similarity of 1-(4-chloro-2-fluoro-5-propargyloxyphenyl)-3-thiourea Derivatives
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Soung Min-Gyu
Park Kwan-Yong
Song Jong-Hwan
Seong Nak-Do
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Abstract
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In the search for third generation herbicidal cyclic imide derivatives, the average values of herbicidal activity (pI50) in vivo (pre-emergence) of 40 new peroxidizing herbicides, 1-(4-chloro-2-fluoro-5-propargyloxyphenyl)thiourea derivatives (1-40) against rice plant (Orysa sativa) and barnyard grass (Echinochlor crus-galli) were studied. The molecular similarity between protoporphyrinogen IX (protogen) as the substrate of protox enzyme and Urea derivatives (1-40) was discussed quantitatively. The diallyl (20) and 3-nitro substituent (33) showed the selective herbicidal activity against barnyard grass. Allyl substituent (8) and their molecular similarity indice (S=0.81) showed the highest levels of herbicidal activity (pI50=4.71). Also, similarity indices (S) and superimposed volume (C) of protogen and aryl-substituents (21-40) showed good correlation.
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KEYWORD
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1-(4-chloro-2-fluoro-5-propargyloxyphenyl)-3-thiourea derivatives, average herbicidal activities (pI50), molecular similarity indice
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